Haku
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Lytic Epstein-Barr virus infection in patients with rheumatoid arthritis
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Allergic asthma and rhinovirus infections in a birth cohort study in Finland and Estonia
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
A new method for long-term culturing of intestinal biopsies derived from Celiac Disease patients using mice as carriers
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Celiac disease (CD) is a complex disorder with no bona fide animal model that would exhibit all the features of the disorder. The small-intestinal mucosal biopsies commonly used to study the disease present a limiting ...
Catalytic mechanism for reduction of bicarbonate in the active site of formate dehydrogenase
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Formate dehydrogenases (FDHs) are a set of mostly homodimeric oxidoreductases that catalyze the oxidation of formate to carbon dioxide with the concurrent reduction of NAD+ to NADH. These enzymes are common to methylotropic ...
Peptidase Inhibitor 15 as a potential target of miR-32 and functional consequences of PI15 overexpression to PC-3 prostate cancer cell line
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Eturauhassyöpä on miesten yleisin syöpä länsimaissa. Syövän vaarallisuuden määrää suurelta osin sen kyky tunkeutua ympäröivään kudokseen ja lähettää etäispesäkkeitä. Eturauhassyövän leviämiseen ja metastaasiin ...
Optimizing differentiation of human pluripotent stem cells towards corneal epithelium
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Limbal stem cell deficiency (LSCD) is a potentially blinding corneal disease caused by trauma, such as chemical burn, inflammation, or hereditary factors. LSCD is characterized by dysfunction of limbal ...
Interactions between estrogen and bone morphogenetic proteins in breast cancer cells
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Breast cancer is the second most common cancer in the world after lung cancer, and the most common cancer among women. The risk factors for breast cancer include different hormonal factors and consequently, ...
Activation of Intracellular Signalling Pathways in Adipose Stem Cell- mediated Immunosuppression
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Adipose tissue is a source of multipotent adipose stromal/stem cells (ASCs). ASCs have excellent proliferation and multilineage differentiation capacity, low immunogenicity and promising immunosuppressive ...
Impact of BMP-2 releasing scaffolds on human adipose stem cell differentiation
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Human adipose tissue is a good source of mesenchymal (adipose) stem cells which can be used in bone tissue engineering both in studying differentiation and for treating patients. Bone morphogenetic protein 2 (BMP-2) is ...
A pipeline to optimize metabolic pathways in the synthetically regulated Saccharomyces cerevisiae using tryptophan pathway as an example
(2016)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Cell factories are currently used to produce biochemicals for nutrition, pharma, medical, and energy industries with a high future potential and interest among these and other industries. General ...