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The Effects of Inhibiting Mechanotransductive Cell Signaling Pathways in Human Bone Marrow Stromal Cells in 2D vs. 3D Culture
(2017)
Diplomityö
Diplomityö
Mechanotransduction is the process of mechanical information transfer between a cell and its surroundings into biochemical responses. Involved in mechanotransduction are several components: extracellular matrix (ECM), ...
Inhibition of fibroblast growth factor receptor in FGFR3:TACC3 fusion positive glioblastoma cells
(2017)
Diplomityö
Diplomityö
Glioblastoma multiforme is the most common of adult primary brain tumors. It is a highly aggressive form of diffuse gliomas and with current treatments median life expectancy of patients with glioblastoma is approximately ...
Enhancing the Structural Maturation and Attachment of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes on Textile Surfaces
(2017)
Diplomityö
Diplomityö
Cardiovascular diseases are one of the leading causes of death in the world. In 2012 ~30% of all deaths were due to cardiovascular diseases. There is a need for new research, drug testing and treatment methods. Tissue ...
Lääkeaineiden kulkeutuminen ja poistuminen urbaanin hydrologisen kierron aikana
(2017)
Diplomityö
Diplomityö
Tässä työssä tavoitteena oli selvittää lääkeaineiden esiintyminen ja poistuminen urbaanin hydrologisen kierron aikana todellisessa pienen mittakaavan ympäristössä. Lääkeaineiden tutkimus jätevesissä ja ympäristössä on ...
Reliability and Limitations of Compression Testing of Various Biomaterials
(2017)
Diplomityö
Diplomityö
Tissue-engineered scaffolds should mimic, as closely as possible, the one of the tissues to be replaced. Hence, mechanical tests are of paramount importance. However, as there are various biomaterials, with distinct ...
A screen for biofilm mutant Mycobacterium marinum
(2017)
Diplomityö
Diplomityö
Mycobacterium tuberculosis infects millions of people every year and in 2015 1.8 million people died from the disease. The main problem is that M. tuberculosis has a natural resistance to many antibiotics. Studying of M. ...
A System for Intraoperative Cancer Margin Detection by Diathermy Smoke Analysis
(2017)
Diplomityö
Diplomityö
In this thesis, a method and system capable of intraoperative cancer margin detection, with potential to improve the current methodology, is introduced, tested and validated. The system is based on diathermy smoke analysis ...
Adhesion Ligand-Presenting Hydrogels for Studying Stem Cell Behaviours in Three Dimensions
(2017)
Diplomityö
Diplomityö
In their natural microenvironment, stem cells are surrounded by various mechanical and biochemical signals, and growing evidence suggests that, similarly to the biochemical cues, the biophysical properties of the ...
Advanced surface treatment of elastomeric polydimethylsiloxane for cell stretching applications
(2017)
Diplomityö
Diplomityö
Polydimethylsiloxane (PDMS) elastomer is widely used in dynamic biological microfluidic applications. Hydrophobic pristine PDMS does not support cell attachment and culture, especially in dynamic conditions. Regardless, ...