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Human Prostate Tissue MicroRNAs and Their Predicted Target Pathways Linked to Prostate Cancer Risk Factors
(2022)
Syventävä työ
Syventävä työ
MikroRNA:t (miRNA:t) ovat molekyylejä, jotka osallistuvat geenien transkription jälkeiseen säätelyyn estämällä lähetti-RNA:n toimintaa. Niillä on osoitettu olevan tärkeä rooli eturauhassyövän kehittymisessä, etenemisessä ...
Changes in 3D genome organization in prostate cancer
(2021)
Pro gradu -tutkielma
Pro gradu -tutkielma
Computational analysis of prostate cancer tumor microenvironment
(2022)
Pro gradu -tutkielma
Pro gradu -tutkielma
Prostate cancer is one of the most frequently diagnosed cancers in men worldwide. If the cancer is detected at an early stage, the prognosis is usually good. However, some prostate cancers are more aggressive and develop ...
Antihypertensive drugs and prostate cancer survival after radical prostatectomy in Finland – a nationwide cohort study
(2018)
Syventävä työ
Syventävä työ
Tietyt verenpainelääkkeet, kuten ATR-salpaajat sekä ACE-estäjät, on yhdistetty parempaan ennusteeseen eturauhassyöpäpotilailla. Me tutkimme verenpainelääkkeiden ja eturauhassyöpäpotilaiden kuolleisuuden välistä yhteyttä ...
TRIM24 and TDP-43 in prostate cancer
(2018)
Syventävä työ
Syventävä työ
Prostate cancer has a high phenotypic homo- and genetic heterogeneity combined with highly variant clinical behavior. This creates a complex problem for the treatment and prediction of the prognoses of the patients. This ...
Targeting the genes of 9p13.3 amplicon in prostate cancer
(2015)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Prostate cancer is the most common cancer among men worldwide, and the molecular mechanisms involved in the disease still remain poorly understood. Prostate cancer is commonly associated with genomic ...
Tumor evolution and heterogeneity analysis of multiregional prostate cancer samples
(2020)
Diplomityö
Diplomityö
Accumulation of mutations in the genomes of cells during lifetime can lead to uncontrollably dividing and misbehaving cell populations, that can ultimately cause the cancer onset. Investigating these changes in the genome ...
Mutational analysis of non-coding genome in prostate cancer using whole genome sequencing
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Prostate Cancer is a lethal disease characterized as progressive and possessing distinct molecular heterogeneity during its timespan. Vast number of abnormalities has been reported till now with number of somatic mutations ...
Blood cholesterol, tumor clinical characteristics and risk of prostate cancer progression after radical prostatectomy
(2021)
Syventävä työ
Syventävä työ
BACKGROUND: The effects of blood cholesterol levels on prostate cancer prognosis are unclear. We explored the associations between blood cholesterol levels and prostate cancer clinical characteristics including Gleason ...
Renin-Angiotensin System in Prostate Cancer Cells
(2021)
Pro gradu -tutkielma
Pro gradu -tutkielma