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Treatment response of colorectal cancer liver metastases to neoadjuvant or conversion therapy : a prospective multicentre follow-up study using MRI, diffusion-weighted imaging and 1H-MR spectroscopy compared with histology (subgroup in the RAXO trial)
BACKGROUND: Colorectal cancer liver metastases respond to chemotherapy and targeted agents not only by shrinking, but also by morphologic and metabolic changes. The aim of this study was to evaluate the value of advanced ...
Estimating the rate of overdiagnosis with prostate cancer screening : evidence from the Finnish component of the European Randomized Study of Screening for Prostate Cancer
PURPOSE: Screening for prostate cancer may have limited impact on decreasing prostate cancer-related mortality. A major disadvantage is overdiagnosis, whereby lesions are identified that would not have become evident during ...
Keyhole versus Sugarbaker techniques in parastomal hernia repair following ileal conduit urinary diversion : a retrospective nationwide cohort study
Background: Previous research on parastomal hernia repair following ileal conduit urinary diversion is limited. This nationwide cohort study aims to present the results of keyhole and Sugarbaker techniques in parastomal ...
Centralized repeated resectability assessment of patients with colorectal liver metastases during first-line treatment : prospective study
BACKGROUND: Metastasectomy is probably underused in metastatic colorectal cancer. The aim of this study was to investigate the effect of centralized repeated assessment on resectability rate of liver metastases. METHODS: ...
Primary care practitioners' diagnostic action when the patient may have cancer : an exploratory vignette study in 20 European countries
OBJECTIVES: Cancer survival rates vary widely between European countries, with differences in timeliness of diagnosis thought to be one key reason. There is little evidence on the way in which different healthcare systems ...
Liproca Depot : A New Antiandrogen Treatment for Active Surveillance Patients
BACKGROUND: There is increasing interest in nonmorbid treatments for low- and intermediate-risk prostate cancer with fewer side effects than surgery or radiotherapy. OBJECTIVE: To investigate the tolerability, safety, and ...
Outcomes of prostate cancer screening among men using antidiabetic medication
Diabetic men have decreased risk for prostate cancer (PCa) overall and lower PSA compared to non-diabetics. This may affect the outcomes of PSA-based screening. We investigated the effect of PSA-based screening at 4-year ...
Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users : A population-based cohort study
PURPOSE: Statins' cholesterol-lowering efficacy is well-known. Recent epidemiological studies have found that inhibition of cholesterol synthesis may have beneficial effects on prostate cancer (PCa) patients, especially ...
Female patients with follicular lymphoma have a better prognosis if primary remission lasts over 24 months
Findings regarding the role of sex in follicular lymphoma (FL) are contradictory and the prognostic value of sex among patients with early progression of disease (POD) remains unclear. We collected real-life data from nine ...
Local relapse of soft tissue sarcoma of the extremities or trunk wall operated on with wide margins without radiation therapy
Background: The quality of surgical margins is the most important factor affecting local control in soft tissue sarcoma (STS). Despite this, there is no universally accepted consensus on the definition of an adequate ...