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Random forest machine learning method outperforms prehospital National Early Warning Score for predicting one-day mortality: A retrospective study

Pirneskoski, Jussi; Tamminen, Joonas; Kallonen, Antti; Nurmi, Jouni; Kuisma, Markku; Olkkola, Klaus T.; Hoppu, Sanna (2020)
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Aim of the study The National Early Warning Score (NEWS) is a validated method for predicting clinical deterioration in hospital wards, but its performance in prehospital settings remains controversial. Modern machine ...

The Cardiovascular-Mortality-Based Estimate for Normal Range of the Ankle–Brachial Index (ABI)

Peltonen, Essi; Laivuori, Mirjami; Vakhitov, Damir; Korhonen, Päivi; Venermo, Maarit; Hakovirta, Harri (2022)
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Background: The ankle–brachial index (ABI) is a first-line examination in cardiovascular risk evaluation. Since cut-off values for normal ABI vary, the aim of the present study was to identify the cardiovascular-mortality-based ...

Association between spinal disorders and different domains of physical activity among young adult men

Honkanen, Tuomas; Vaara, Jani P.; Pihlajamäki, Harri; Västilä, Ville; Kyröläinen, Heikki (2022-09-08)
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Background: There is limited evidence of how physical activity (PA) associates with low back pain (LBP) and neck pain (NP). Particularly, the association between occupational or commuting PA and LBP/NP is unclear. The aim ...

Female patients with follicular lymphoma have a better prognosis if primary remission lasts over 24 months

Rajamäki, Aino; Sunela, Kaisa; Prusila, Roosa E.I.; Kuusisto, Milla E.L.; Mercadal, Santiago; Selander, Tuomas; Kuitunen, Hanne; Pollari, Marjukka; Jantunen, Esa; Nystrand, Ilja; Sancho, Juan Manuel; Sorigue, Marc; Kuittinen, Outi (2021)
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Findings regarding the role of sex in follicular lymphoma (FL) are contradictory and the prognostic value of sex among patients with early progression of disease (POD) remains unclear. We collected real-life data from nine ...

Method for the Intraoperative Detection of IDH Mutation in Gliomas with Differential Mobility Spectrometry

Haapala, Ilkka; Kondratev, Anton; Roine, Antti; Mäkelä, Meri; Kontunen, Anton; Karjalainen, Markus; Laakso, Aki; Koroknay-Pál, Päivi; Nordfors, Kristiina; Haapasalo, Hannu; Oksala, Niku; Vehkaoja, Antti; Haapasalo, Joonas (2022-05)
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Isocitrate dehydrogenase (IDH) mutation status is an important factor for surgical decision-making: patients with IDH-mutated tumors are more likely to have a good long-term prognosis, and thus favor aggressive resection ...

Angiogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Nanofibrillated Cellulose Hydrogel

Koivunotko, Elle; Snirvi, Jasmi; Merivaara, Arto; Harjumäki, Riina; Rautiainen, Swarna; Kelloniemi, Minna; Kuismanen, Kirsi; Miettinen, Susanna; Yliperttula, Marjo; Koivuniemi, Raili (2022-10)
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Adipose-derived mesenchymal stromal cells (ASCs) hold great potential for cellular therapies by having immunomodulatory behavior and tissue regenerative properties. Due to the capability of ASCs to differentiate into ...

Impact of Timing of Surgery and Adjuvant Treatment on Survival of Adult IDH–wild-type Glioblastoma : A Single-center Study of 392 Patients

Natukka, Tuomas; Haapasalo, Joonas; Kivioja, Tomi; Rajala, Linnea; Raitanen, Jani; Nevalainen, Jaakko; Lahtela, Sirpa-Liisa; Nordfors, Kristiina; Rauhala, Minna; Jukkola, Arja; Frösen, Juhana; Helén, Pauli; Auvinen, Anssi; Haapasalo, Hannu (2023)
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Background: The purpose of our study was to analyze the impact of time interval from referral to surgery and from surgery to adjuvant treatment on survival of adult isocitrate dehydrogenase–wild-type (IDH-wt) glioblastomas. ...

Assessment of chronic limb threatening ischemia using thermal imaging

Pakarinen, Tomppa; Joutsen, Atte; Oksala, Niku; Vehkaoja, Antti (2023-01)
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Objectives: Current chronic limb threatening ischemia (CLTI) diagnostics require expensive equipment, using ionizing radiation or contrast agents, or summative surrogate methods lacking in spatial information. Our aim is ...

Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells

Hyväri, Laura; Vanhatupa, Sari; Ojansivu, Miina; Kelloniemi, Minna; Pakarinen, Toni Karri; Hupa, Leena; Miettinen, Susanna (2023-01)
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Bioactive glass (BaG) materials are increasingly used in clinics, but their regulatory mechanisms on osteogenic differentiation remain understudied. In this study, we elucidated the currently unknown role of the p38 MAPK ...

Minimal important difference and patient acceptable symptom state for pain, Constant-Murley score and Simple Shoulder Test in patients with subacromial pain syndrome

Kanto, Kari; Lähdeoja, Tuomas; Paavola, Mika; Aronen, Pasi; Järvinen, Teppo L.N.; Jokihaara, Jarkko; Ardern, Clare L.; Karjalainen, Teemu V.; Taimela, Simo (2021-12)
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Background: The results of clinical trials should be assessed for both statistical significance and importance of observed effects to patients. Minimal important difference (MID) is a threshold denoting a difference that ...