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Nucleotide-binding mechanisms in pseudokinases
Pseudokinases are classified by the lack of one or several of the highly conserved motifs involved in nucleotide (nt) binding or catalytic activity of protein kinases (PKs). Pseudokinases represent ∼10% of the human kinome ...
Osallistuvan journalismin ankkuroivat käytännöt
Altered expression of epithelial-to-mesenchymal transition proteins in extraprostatic prostate cancer
Epithelial to mesenchymal transition (EMT) of cancer cells involves loss of epithelial polarity and adhesiveness, and gain of invasive and migratory mesenchymal behaviours. EMT occurs in prostate cancer (PCa) but it is ...
Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study
Background Chronological aging-associated changes in the human DNA methylome have been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites have been identified as aging-associated in multiple ...
Diasporas and conflicts–understanding the nexus
Breast cancer risk in families with mutations in PALB2
BACKGROUND: Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown. METHODS: We ...
Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer
BACKGROUND: In patients with metastatic breast cancer that is positive for human epidermal growth factor receptor 2 (HER2), progression-free survival was significantly improved after first-line therapy with pertuzumab, ...