Viitteet 1-10 / 545
Pot-economy autooxidative condensation of 2-Aryl-2-lithio-1,3-dithianes
The autoxidative condensation of 2-aryl-2-lithio-1,3-dithianes is here reported. Treatment of 2-aryl-1,3-dithianes with n-BuLi in the absence of any electrophile leads to condensation of three molecules of 1,3-dithianes ...
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories : a pooled analysis of 2181 population-based studies with 65 million participants
Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), ...
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed ...
The TAXINOMISIS Project : A multidisciplinary approach for the development of a new risk stratification model for patients with asymptomatic carotid artery stenosis
INTRODUCTION: Asymptomatic carotid artery stenosis (ACAS) may cause future stroke and therefore patients with ACAS require best medical treatment. Patients at high risk for stroke may opt for additional revascularization ...
Metabolic profiles of socio-economic position : a multi-cohort analysis
BACKGROUND: Low socio-economic position (SEP) is a risk factor for multiple health outcomes, but its molecular imprints in the body remain unclear. METHODS: We examined SEP as a determinant of serum nuclear magnetic resonance ...
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition : a drug-target Mendelian randomization analysis
AIMS : Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. To investigate the molecular ...
Efficacy and safety of darolutamide in Japanese patients with nonmetastatic castration-resistant prostate cancer : a sub-group analysis of the phase III ARAMIS trial
Background: Darolutamide, an oral androgen receptor inhibitor, has been approved for treating nonmetastatic castration-resistant prostate cancer (nmCRPC), based on significant improvements in metastasis-free survival (MFS) ...
Common Core Assessments in follow-up studies of adults born preterm : Recommendation of the Adults Born Preterm International Collaboration
Background: Of all newborns, 1%-2% are born very preterm (VP; <32 weeks) or with very low birthweight (VLBW; ≤1500 g). Advances in prenatal and neonatal care have substantially improved their survival, and the first ...
Streamers: The new wave of digital entreprenurship? Extant corpus and future research agenda
Video content creation by “amateur” private users has taken on professional (i.e. work) characteristics. The emergence of user-centric video sharing services (e.g. YouTube, Twitch, Mixer) has set the scene for the rise of ...
Case Study : Creating A Business Value in Immersive Journalism
The litmus test for all new gadgets and technologies is the market: whether, or not, consumers buy and use them. A meaningful innovation is really created only along market success. This chapter explains the business value ...