Haku
Viitteet 1-10 / 822
Maternal childbirth experience and time of delivery : A retrospective 7-year cohort study of 105 847 parturients in Finland
(2021-06-16)
- article
Objectives To explore how the time of delivery influences childbirth experience. Design A retrospective cohort study. Setting Childbirth in the four Helsinki and Uusimaa Hospital District hospitals, Finland, from 2012 to ...
Evaluating the direct effects of childhood adiposity on adult systemic metabolism : A multivariable Mendelian randomization analysis
(2021)
- article
Background: Individuals who are obese in childhood have an elevated risk of disease in adulthood. However, whether childhood adiposity directly impacts intermediate markers of this risk, independently of adult adiposity, ...
Clinical value of bronchodilator response for diagnosing asthma in steroid-naïve adults
(2021-12-13)
- article
Spirometry and testing for bronchodilator response have been recommended to detect asthma, and a bronchodilator response (BDR) of ≥12% and ≥200 mL has been suggested to confirm asthma. However, the clinical value of ...
3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography
(2021-06)
- article
Background: Radiation therapy (RT) results in myocardial changes consisting of diffuse fibrosis, which may result in changes in diastolic function. Objectives: The aim of this study was to explore RT-associated changes in ...
The Association of Atrial Fibrillation before Percutaneous Coronary Intervention with 1-Year Outcome in ST-elevation Myocardial Infarction patients : The Outcome of STEMI patients with Pre-PCI AF
(2021)
- article
Background: We aimed to determine the association of atrial fibrillation (AF) with 1-year outcome in STEMI patients undergoing primary PCI. Methods: Patients (n=8,830) enrolled in the Trial of Routine Aspiration Thrombectomy ...
Influence of early-lifebody mass index and systolic blood pressure on left ventricle in adulthood : The Cardiovascular Risk in Young Finns Study
(2020-12-14)
- article
BACKGROUND: Increased left ventricular mass (LVM) predicts cardiovascular eventsandmortality. The objective of this study was to determine whether early-life exposures to body mass index (BMI) and systolic blood pressure ...
The mutational constraint spectrum quantified from variation in 141,456 humans
(2020-05-28)
- article
Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the function of an organism will be depleted of ...
Transcript expression-aware annotation improves rare variant interpretation
(2020-05-28)
- article
The acceleration of DNA sequencing in samples from patients and population studies has resulted in extensive catalogues of human genetic variation, but the interpretation of rare genetic variants remains problematic. A ...
Midlife improvements in financial situation are associated with a reduced dementia risk later in life : the CAIDE 30-year study
(2020-11)
- article
OBJECTIVES: Perceived financial strain is associated with various health conditions, but it is unknown whether it is associated with an increased risk for dementia. The goal is to examine the associations between midlife ...
Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study
(2022)
- article
Aims/hypothesis: Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes. ...