Trepo - Selaus tiedekunnan mukaan (- 2018)
Viitteet 1-20 / 199
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A Comparative Analysis of Thermodynamic Stability of Electron transport Chain Complex I Proteins and the Maximum Life Span of Host Organisms
(2014)
Pro gradu -tutkielmaBackground and Aims: "Mitochondrial theory of ageing" is an established theory which states that there is a correlation between Maximum Life Span (MLSP) of an organism and its mitochondrial free radical production. Here ... -
A comprehensive repertoire of tRNA-derived fragments in prostate cancer
(2016)
articleProstate cancer (PCa) is the most common cancer among men in developed countries. Although its genetic background is thoroughly investigated, rather little is known about the role of small non-coding RNAs (sncRNA) in this ... -
A Functional Study of the Drosophila Host Defense
Acta Electronica Universitatis Tamperensis : 1511 (Tampere University Press, 2015)
ArtikkeliväitöskirjaIhmisen immuunijärjestelmä muodostuu synnynnäisestä ja hankitusta immuniteetistä. Synnynnäinen immuniteetti on tärkeä osa meidän immuunivastettamme, sillä se toimii ensilinjan puolustusjärjestelmänä taudinaiheuttajia ... -
A Highly Sensitive Porous Silicon (P-Si)-Based Human Kallikrein 2 (hK2) Immunoassay Platform toward Accurate Diagnosis of Prostate Cancer
(2015)
articleLevels of total human kallikrein 2 (hK2), a protein involved the pathology of prostate cancer (PCa), could be used as a biomarker to aid in the diagnosis of this disease. In this study, we report on a porous silicon antibody ... -
A new method for long-term culturing of intestinal biopsies derived from Celiac Disease patients using mice as carriers
(2016)
Pro gradu -tutkielmaCeliac disease (CD) is a complex disorder with no bona fide animal model that would exhibit all the features of the disorder. The small-intestinal mucosal biopsies commonly used to study the disease present a limiting ... -
A novel chimeric avidin with increased thermal stability using DNA shuffling
(2014)
articleAvidins are a family of proteins widely employed in biotechnology. We have previously shown that functional chimeric mutant proteins can be created from avidin and avidin-related protein 2 using a methodology combining ... -
A Novel Strategy for Live Detection of Viral Infection in Drosophila melanogaster
(2016)
articleWe have created a transgenic reporter for virus infection, and used it to study Nora virus infection in Drosophila melanogaster. The transgenic construct, Munin, expresses the yeast transcription factor Gal4, tethered to ... -
A pipeline to optimize metabolic pathways in the synthetically regulated Saccharomyces cerevisiae using tryptophan pathway as an example
(2016)
Pro gradu -tutkielmaBackground and aims: Cell factories are currently used to produce biochemicals for nutrition, pharma, medical, and energy industries with a high future potential and interest among these and other industries. General ... -
A Rolling Circle Replication Mechanism Produces Multimeric Lariats of Mitochondrial DNA in Caenorhabditis elegans
(2015)
articleMitochondrial DNA (mtDNA) encodes respiratory complex subunits essential to almost all eukaryotes; hence respiratory competence requires faithful duplication of this molecule. However, the mechanism(s) of its synthesis ... -
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
(2014)
articleBackground Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play ... -
Activation of Intracellular Signalling Pathways in Adipose Stem Cell- mediated Immunosuppression
(2016)
Pro gradu -tutkielmaBackground and aims: Adipose tissue is a source of multipotent adipose stromal/stem cells (ASCs). ASCs have excellent proliferation and multilineage differentiation capacity, low immunogenicity and promising immunosuppressive ... -
Adequate Th2-Type Response Associates with Restricted Bacterial Growth in Latent Mycobacterial Infection of Zebrafish
(2014)
articleTuberculosis is still a major health problem worldwide. Currently it is not known what kind of immune responses lead to successful control and clearance of Mycobacterium tuberculosis. This gap in knowledge is reflected by ... -
Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
(2015)
articleBackground Changes in DNA methylation are among the mechanisms contributing to the ageing process. We sought to identify ageing-associated DNA methylation changes at single-CpG-site resolution in blood leukocytes and ... -
Allergic asthma and rhinovirus infections in a birth cohort study in Finland and Estonia
(2016)
Pro gradu -tutkielma -
Altered expression of epithelial-to-mesenchymal transition proteins in extraprostatic prostate cancer
(2016)
articleEpithelial to mesenchymal transition (EMT) of cancer cells involves loss of epithelial polarity and adhesiveness, and gain of invasive and migratory mesenchymal behaviours. EMT occurs in prostate cancer (PCa) but it is ... -
Angiotensin(1-7) and ACE2, “The Hot Spots” of Renin-Angiotensin System, Detected in the Human Aqueous Humor
(2015)
articleBACKGROUND: The main purpose of the study was to establish whether essential components of the renin-angiotensin system (RAS) exist in the human aqueous humor. METHODS: Forty-five patients ≥ 60 (74±7) years of age ... -
Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models
(2015)
articleCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal ... -
Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis
(2015)
articleBackground A parasitic roundworm, Ascaris lumbricoides, is the causative agent of ascariasis, with approximately 760 million cases around the world. Helminthic infections occur with a high prevalence mostly in tropical ... -
Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer : statistical evaluation of epistasis
(2014)
articleUnderstanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the ...