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Higher sensitivity to ouabain-induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes than human adult heart tissue despite similar Na<sup>+</sup>/K<sup>+</sup>-ATPase pump current amplitudes
(2026)
articleBackground and Purpose: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the ... -
Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective
(02 / 2023)
reviewarticleModels based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived ... -
PDE8 Inhibition and Its Impact on i <sup>Ca,L</sup>in Persistent Atrial Fibrillation: Evaluation of PDE8 as a Potential Drug Target
(2024)
articleAtrial fibrillation (AF) poses a significant therapeutic challenge with drug interventions showing only limited success. Phosphodiesterases (PDE) regulate cardiac electrical stability and may represent an interesting target. ... -
Regulation of APD and Force by the Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue
(05.08.2022)
articleThe physiological importance of NCX in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is not well characterized but may depend on the relative strength of the current, compared to adult cardiomyocytes, ...
