Trepo - Selaus tekijän mukaan "Gaballah, Mahmoud" - Trepo

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Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Gaballah, Mahmoud; Penttinen, Kirsi; Kreutzer, Joose; Mäki, Antti Juhana; Kallio, Pasi; Aalto-Setälä, Katriina (03 / 2022)
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Ischemic heart disease (IHD) is one of the leading causes of mortality worldwide. Preserv-ing functionality and preventing arrhythmias of the heart are key principles in the management of patients with IHD. Levosimendan, ...
A hypoxia-on-a-chip platform for modeling ischemic arrhythmogenesis and evaluating the effects of levosimendan and OR-1896 on ischemic human iPSC-derived cardiomyocytes

Gaballah, Mahmoud; Walls, Kaisla; Zakzook, Fatma; Kreutzer, Joose; Levijoki, Jouko; Aalto-Setälä, Katriina (2025)
article

Acute hypoxia is a major contributor to cardiomyocyte damage and dysfunction in ischemic heart disease, and the effective therapeutic strategies remain limited. Levosimendan, a calcium sensitizer with both inotropic and ...
Metabolic fatty acid substrates enhance the structural and mechanical performance of human-induced pluripotent stem cell-derived cardiomyocytes

Gaballah, Mahmoud; Penttinen, Kirsi; Prajapati, Chandra; Aalto-Setälä, Katriina (2026)
article

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a powerful platform for disease modeling, drug discovery, and regenerative therapies. However, their clinical and research utility remains limited ...