Trepo - Selaus tekijän mukaan "Azizi, Latifeh"
Viitteet 1-20 / 23
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Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva
(2022)
articleCarbonic anhydrases (CA, EC 4.2.1.1) catalyze the hydration of carbon dioxide and take part in many essential physiological processes. In humans, 15 CAs are characterized, including the only secreted isoenzyme CA VI. CA ... -
Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis
(2021)
articleAbstract: Trichomonas vaginalis is a unicellular parasite and responsible for one of the most common sexually transmittable infections worldwide, trichomoniasis. Carbonic anhydrases (CAs) are enzymes found in all lifeforms ... -
Cancer associated talin point mutations disorganise cell adhesion and migration
(2021)
articleTalin-1 is a key component of the multiprotein adhesion complexes which mediate cell migration, adhesion and integrin signalling and has been linked to cancer in several studies. We analysed talin-1 mutations reported in ... -
Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding
(12 / 2020)
articleBinding of the intracellular adapter proteins talin and its cofactor, kindlin, to the integrin receptors induces integrin activation and clustering. These processes are essential for cell adhesion, migration, and organ ... -
Extrusion-Based Bioprinting of Multilayered Nanocellulose Constructs for Cell Cultivation Using In Situ Freezing and Preprint CaCl2 Cross-Linking
(30.12.2020)
articleExtrusion-based bioprinting with a preprint cross-linking agent and an in situ cooling stage provides a versatile method for the fabrication of 3D structures for cell culture. We added varying amounts of calcium chloride ... -
The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering
(12.10.2020)
articleIntegrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activate the heterodimeric integrin, and ... -
Microfluidics-Based Force Spectroscopy Enables High-Throughput Force Experiments with Sub-Nanometer Resolution and Sub-Piconewton Sensitivity
(2023)
articleSeveral techniques have been established to quantify the mechanicals of single molecules. However, most of them show only limited capabilities of parallelizing the measurement by performing many individual measurements ... -
De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function
(09 / 2025)
articleTalin-1 is a central integrin adapter protein connecting cytoplasmic domains of integrins to the cytoskeleton. These talin-1-mediated mechanical linkages are crucial for cellular functions such as cell movement and connections ... -
Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions
(2021)
articleThe LIM domain-dependent localization of the adapter protein paxillin to β3 integrin-positive focal adhesions (FAs) is not mechanistically understood. Here, by combining molecular biology, photoactivation and FA-isolation ... -
Structure-function of Talin1 : An integrin adaptor protein involved in health and disease
Tampere University Dissertations - Tampereen yliopiston väitöskirjat : 832 (Tampere University, 2023)
ArtikkeliväitöskirjaSolu on organismin pienin rakenteellinen ja toiminnallinen yksikkö. Solut ovat dynaamisesti vuorovaikutuksessa ympäröivän ympäristönsä kanssa. Solujen välisen tilan täyttävää ainetta, joka on proteiinien ja polysakkaridien ... -
Surface Modification of Bioactive Glass Promotes Cell Attachment and Spreading
(2021)
articlePhosphate glasses have several advantages over traditional silicate-based bioglasses but are inferior in the crucial step of cell attachment to their surface. Here, as a proof of concept, we analyze fibroblast attachment ... -
Surface Modification of Bioresorbable Phosphate Glasses for Controlled Protein Adsorption
(2021)
articleThe traditional silicate bioactive glasses exhibit poor thermal processability, which inhibits fiber drawing or sintering into scaffolds. The composition of the silicate glasses has been modified to enable hot processing. ... -
Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms
(15.12.2022)
articleAdhesion of cells to the extracellular matrix (ECM) must be exquisitely coordinated to enable development and tissue homeostasis. Cell-ECM interactions are regulated by multiple signalling pathways that coordinate the ... -
Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease
(01.11.2024)
articleVariants of talin-1 (TLN1) have recently been linked with spontaneous coronary artery dissection (SCAD) a condition where a tear can form in the wall of a heart artery necessitating immediate medical care. One talin-1 ...
