Trepo - Selaus tekijän mukaan "Aakula, Anna"

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    • RAS and PP2A activities converge on epigenetic gene regulation 

      Aakula, Anna; Sharma, Mukund; Tabaro, Francesco; Nätkin, Reetta; Kamila, Jesse; Honkanen, Henrik; Schapira, Matthieu; Arrowsmith, Cheryl; Nykter, Matti; Westermarck, Jukka (2023)
      article
      <p>RAS-mediated human cell transformation requires inhibition of the tumor suppressor protein phosphatase 2A (PP2A). However, the phosphoprotein targets and cellular processes in which RAS and PP2A activities converge ...

    • Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A 

      Pavic, Karolina; Gupta, Nikhil; Omella, Judit Domènech; Derua, Rita; Aakula, Anna; Huhtaniemi, Riikka; Määttä, Juha A.; Höfflin, Nico; Okkeri, Juha; Wang, Zhizhi; Kauko, Otto; Varjus, Roosa; Honkanen, Henrik; Abankwa, Daniel; Köhn, Maja; Hytönen, Vesa P.; Xu, Wenqing; Nilsson, Jakob; Page, Rebecca; Janssens, Veerle; Leitner, Alexander; Westermarck, Jukka (2023)
      article
      <p>The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly understood. Here, we report molecular level details ...