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    • The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels 

      -, -; Romanello, Marina; Napoli, Claudia Di; Drummond, Paul; Green, Carole; Kennard, Harry; Lampard, Pete; Scamman, Daniel; Arnell, Nigel; Ayeb-Karlsson, Sonja; Ford, Lea Berrang; Belesova, Kristine; Bowen, Kathryn; Cai, Wenjia; Callaghan, Max; Campbell-Lendrum, Diarmid; Chambers, Jonathan; Daalen, Kim R van; Dalin, Carole; Dasandi, Niheer; Dasgupta, Shouro; Davies, Michael; Dominguez-Salas, Paula; Dubrow, Robert; Ebi, Kristie L; Eckelman, Matthew; Ekins, Paul; Escobar, Luis E; Georgeson, Lucien; Graham, Hilary; Gunther, Samuel H; Hamilton, Ian; Hang, Yun; Hänninen, Risto; Hartinger, Stella; He, Kehan; Hess, Jeremy J; Hsu, Shih-Che; Jankin, Slava; Jamart, Louis; Jay, Ollie; Kelman, Ilan; Kiesewetter, Gregor; Kinney, Patrick; Kjellstrom, Tord; Kniveton, Dominic; Lee, Jason K W; Lemke, Bruno; Liu, Yang; Liu, Zhao; Taylor, Jonathon (25.10.2022)
      article

    • 24-hour ambulatory blood pressure and cryptogenic ischemic stroke in young adults 

      -, -; Tulkki, Lauri; Martinez-Majander, Nicolas; Haapalahti, Petri; Tolppanen, Heli; Sinisalo, Juha; Repo, Olli; Sarkanen, Tomi; Numminen, Heikki; Ryödi, Essi; Ylikotila, Pauli; Roine, Risto O.; Lautamäki, Riikka; Saraste, Antti; Miettinen, Tuuli; Autere, Jaana; Jäkälä, Pekka; Hedman, Marja; Huhtakangas, Juha; Junttola, Ulla; Putaala, Jukka; Pirinen, Jani (2023)
      article
      <p>Background: In young patients, up to 40% of ischemic strokes remain cryptogenic despite modern-day diagnostic work-up. There are limited data on blood pressure (BP) behavior in these patients. Thus, we aimed to ...

    • 4CMenB Breadth of Immune Response, Immunogenicity, and Safety: Results From a Phase 3 Randomized, Controlled, Observer Blind Study in Adolescents and Young Adults 

      -, -; Nolan, Terry; Bhusal, Chiranjiwi; Beran, Jiří; Bloch, Mark; Cetin, Benhur S; Dinleyici, Ener C; Dražan, Daniel; Kokko, Satu; Koski, Susanna; Laajalahti, Outi; Langley, Joanne M; Rämet, Mika; Richmond, Peter C; Silas, Peter; Tapiero, Bruce; Tiong, Florence; Tipton, Mary; Ukkonen, Benita; Ulukol, Betul; Lattanzi, Maria; Trapani, Mauro; Willemsen, Arnold; Toneatto, Daniela (2024)
      article
      <p>BACKGROUND: Meningococcal serogroup B (MenB) strains are highly diverse. Breadth of immune response for the MenB vaccine, 4CMenB, administered at 0-2, 0-6, or 0-2-6 months, was demonstrated by endogenous ...

    • The additive value of CA19.9 monitoring in a pancreatic cyst surveillance program 

      -, -; Levink, Iris J.M.; Jaarsma, Sanne C.; Koopmann, Brechtje D.M.; van Riet, Priscilla A.; Overbeek, Kasper A.; Meziani, Jihane; Sprij, Marloes L.J.A.; Casadei, Riccardo; Ingaldi, Carlo; Polkowski, Marcin; Engels, Megan M.L.; van der Waaij, Laurens A.; Carrara, Silvia; Pando, Elizabeth; Vornhülz, Marlies; Honkoop, Pieter; Schoon, Erik J.; Laukkarinen, Johanna; Bergmann, Jilling F.; Rossi, Gemma; van Vilsteren, Frederike G.I.; van Berkel, Anne Marie; Tabone, Trevor; Schwartz, Matthijs P.; Tan, Adriaan C.I.T.L.; van Hooft, Jeanin E.; Quispel, Rutger; van Soest, Ellert; Czacko, Laszlo; Bruno, Marco J.; Cahen, Djuna L. (2023)
      article
      <p>Background: Surveillance of pancreatic cysts focuses on the detection of (mostly morphologic) features warranting surgery. European guidelines consider elevated CA19.9 as a relative indication for surgery. We aimed ...

    • The Adjuvanted Recombinant Zoster Vaccine Confers Long-Term Protection Against Herpes Zoster: Interim Results of an Extension Study of the Pivotal Phase 3 Clinical Trials ZOE-50 and ZOE-70 

      -, -; Boutry, Céline; Hastie, Andrew; Diez-Domingo, Javier; Tinoco, Juan Carlos; Yu, Chong Jen; Andrews, Charles; Beytout, Jean; Caso, Covadonga; Cheng, Huey Shinn; Cheong, Hee Jin; Choo, Eun Ju; Curiac, Dan; Di Paolo, Emmanuel; Dionne, Marc; Eckermann, Tamara; Esen, Meral; Ferguson, Murdo; Ghesquiere, Wayne; Hwang, Shinn Jang; Avelino-Silva, Thiago Junqueira; Kosina, Pavel; Liu, Chiu Shong; Markkula, Jukka; Moeckesch, Beate; Murta de Oliveira, Cláudia; Park, Dae Won; Pauksens, Karlis; Pirrotta, Paola; Plassmann, Georg; Pretswell, Carol; Rombo, Lars; Salaun, Bruno; Sanmartin Berglund, Johan; Schenkenberger, Isabelle; Schwarz, Tino; Shi, Meng; Ukkonen, Benita; Zahaf, Toufik; Zerbini, Cristiano; Schuind, Anne; Cunningham, Anthony L. (04 / 2022)
      article
      <p>BACKGROUND: This ongoing follow-up study evaluated the persistence of efficacy and immune responses for 6 additional years in adults vaccinated with the glycoprotein E (gE)-based adjuvanted recombinant zoster ...

    • Adult Severe Asthma Registries: A Global and Growing Inventory 

      -, -; Cushen, Breda; Koh, Mariko Siyue; Tran, Trung N; Martin, Neil; Murray, Ruth; Uthaman, Thendral; Goh, Celine Yun Yi; Vella, Rebecca; Eleangovan, Neva; Bulathsinhala, Lakmini; Maspero, Jorge F; Peters, Matthew J; Schleich, Florence; Pitrez, Paulo; Christoff, George; Sadatsafavi, Mohsen; Torres-Duque, Carlos A; Porsbjerg, Celeste; Altraja, Alan; Lehtimäki, Lauri; Bourdin, Arnaud; Taube, Christian; Papadopoulos, Nikolaos G; Zsuzsanna, Csoma; Björnsdóttir, Unnur; Salvi, Sundeep; Heffler, Enrico; Iwanaga, Takashi; Al-Ahmad, Mona; Larenas-Linnemann, Désirée; van Boven, Job F M; Aarli, Bernt Bøgvald; Kuna, Piotr; Loureiro, Cláudia Chaves; Al-Lehebi, Riyad; Lee, Jae Ha; Marina, Nuria; Bjermer, Leif; Sheu, Chau-Chyun; Mahboub, Bassam; Busby, John; Menzies-Gow, Andrew; Wang, Eileen; Price, David B (2023)
      article
      <p>AIM: The International Severe Asthma Registry (ISAR; http://isaregistries.org/) uses standardised variables to enable multi-country and adequately powered research in severe asthma. This study aims to look at the ...

    • Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 

      -, -; Kyu, Hmwe Hmwe; Vongpradith, Avina; Sirota, Sarah Brooke; Novotney, Amanda; Troeger, Christopher E.; Doxey, Matthew C.; Bender, Rose G.; Ledesma, Jorge R.; Biehl, Molly H.; Albertson, Samuel B.; Frostad, Joseph Jon; Burkart, Katrin; Bennitt, Fiona B.; Zhao, Jeff T.; Gardner, William M.; Hagins, Hailey; Bryazka, Dana; Dominguez, Regina Mae Villanueva; Abate, Semagn Mekonnen; Abdelmasseh, Michael; Abdoli, Amir; Abdoli, Gholamreza; Abedi, Aidin; Abedi, Vida; Abegaz, Tadesse M.; Abidi, Hassan; Aboagye, Richard Gyan; Abolhassani, Hassan; Abtew, Yonas Derso; Abubaker Ali, Hiwa; Abu-Gharbieh, Eman; Abu-Zaid, Ahmed; Adamu, Kidist; Addo, Isaac Yeboah; Adegboye, Oyelola A.; Adnan, Mohammad; Adnani, Qorinah Estiningtyas Sakilah; Afzal, Muhammad Sohail; Afzal, Saira; Ahinkorah, Bright Opoku; Ahmad, Aqeel; Ahmad, Araz Ramazan; Ahmad, Sajjad; Ahmadi, Ali; Liu, Wei; Paudel, Rajan; Rahman, Md Obaidur; Suleman, Muhammad; Vasankari, Tommi Juhani; Wang, Yu (2022)
      article
      <p>Background: The global burden of lower respiratory infections (LRIs) and corresponding risk factors in children older than 5 years and adults has not been studied as comprehensively as it has been in children ...

    • AI is a viable alternative to high throughput screening: a 318-target study 

      -, -; Wallach, Izhar; Bernard, Denzil; Nguyen, Kong; Ho, Gregory; Morrison, Adrian; Stecula, Adrian; Rosnik, Andreana; O’Sullivan, Ann Marie; Davtyan, Aram; Samudio, Ben; Thomas, Bill; Worley, Brad; Butler, Brittany; Laggner, Christian; Thayer, Desiree; Moharreri, Ehsan; Friedland, Greg; Truong, Ha; van den Bedem, Henry; Ng, Ho Leung; Stafford, Kate; Sarangapani, Krishna; Giesler, Kyle; Ngo, Lien; Mysinger, Michael; Ahmed, Mostafa; Anthis, Nicholas J.; Henriksen, Niel; Gniewek, Pawel; Eckert, Sam; de Oliveira, Saulo; Suterwala, Shabbir; PrasadPrasad, Srimukh Veccham Krishna; Shek, Stefani; Contreras, Stephanie; Hare, Stephanie; Palazzo, Teresa; O’Brien, Terrence E.; Van Grack, Tessa; Williams, Tiffany; Chern, Ting Rong; Kenyon, Victor; Lee, Andreia H.; Cann, Andrew B.; Bergman, Bastiaan; Anderson, Brandon M.; Virtanen, Anniina; Musta, Kirsikka; Silvennoinen, Olli; Haikarainen, Teemu (2024)
      article
      High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast ...

    • Analysis of early childhood intestinal microbial dynamics in a continuous-flow bioreactor 

      -, -; Granato, Alessandra; Renwick, Simone; Yau, Christopher; Kong, Tiffany; Daigneault, Michelle C.; Knip, Mikael; Allen-Vercoe, Emma; Danska, Jayne S. (12 / 2024)
      article
      Background: The human gut microbiota is inoculated at birth and undergoes a process of assembly and diversification during the first few years of life. Studies in mice and humans have revealed associations between the ...

    • Anti-viral action against type 1 diabetes autoimmunity: The GPPAD-AVAnT1A study protocol 

      -, -; Hummel, Sandra; Käßl, Alexandra; Arnolds, Stefanie; Achenbach, Peter; Berner, Reinhard; Casteels, Kristina; Hyöty, Heikki; Kordonouri, Olga; Larsson, Helena Elding; Lundgren, Markus; Marcovecchio, M. Loredana; Owen, Catherine; Pfirrmann, Markus; Robson, Steve; Szadkowska, Agnieszka; Szypowska, Agnieszka; Tree, Timothy; Weiss, Andreas; Ziegler, Anette Gabriele; Bonifacio, Ezio (04 / 2025)
      article
      Viral infections in the first year of life are associated with islet autoimmunity and type 1 diabetes risk. The Anti-Viral Action against Type 1 Diabetes Autoimmunity (AVAnT1A)- study is a clinical phase IV investigator ...

    • The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates 

      -, -; Buhigas, Claudia; Warren, Anne Y.; Leung, Wing Kit; Whitaker, Hayley C.; Luxton, Hayley J.; Hawkins, Steve; Kay, Jonathan; Butler, Adam; Xu, Yaobo; Woodcock, Dan J.; Merson, Sue; Frame, Fiona M.; Sahli, Atef; Abascal, Federico; Martincorena, Inigo; Bova, G. Steven; Foster, Christopher S.; Campbell, Peter; Maitland, Norman J.; Neal, David E.; Massie, Charlie E.; Lynch, Andy G.; Eeles, Rosalind A.; Cooper, Colin S.; Wedge, David C.; Brewer, Daniel S. (2022)
      article
      <p>Background: Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In ...

    • Artificial Intelligence in Healthcare: Directions of Standardization 

      -, -; Alcini, Paolo; Baird, Pat; Williams, Peter; Bhattacharyya, SB; Cooper, Todd; de la Cruz, Rich; Kumar, Chandan; Datta, Gora; De Marco, Dorotea Alessandra; Franken, Andreas; Geierhofer, Regina; Goldschmidt, Peter G.; Juuso, Ilkka; Klimenko, Herman; Kung, Antonio; Laroche, Frederic; Lewelling, Joe; Meyer, Martin; Morozov, Sergey; Orlova, Anna; Panagiotis, Telonis; Penzel, Thomas; Ritz, Derek; Sander, Gaur; Shin, Soo-Yong; Värri, Alpo; Vladzimerskiy, Anton; Lebedev, Georgy
      Intelligent Systems Reference Library (2021)
      chapter
      <p>Artificial intelligence (AI) can have a significant positive impact on health and healthcare. AI can be used to improve the quality, efficiency and equity of health care. However, AI has the potential to have ...

    • Assessing fatigue and sleep in chronic diseases using physiological signals from wearables: A pilot study 

      -, -; Antikainen, Emmi; Njoum, Haneen; Kudelka, Jennifer; Branco, Diogo; Rehman, Rana Zia Ur; Macrae, Victoria; Davies, Kristen; Hildesheim, Hanna; Emmert, Kirsten; Reilmann, Ralf; Janneke van der Woude, C.; Maetzler, Walter; Ng, Wan Fai; O’Donnell, Patricio; Van Gassen, Geert; Baribaud, Frédéric; Pandis, Ioannis; Manyakov, Nikolay V.; van Gils, Mark; Ahmaniemi, Teemu; Chatterjee, Meenakshi (14.11.2022)
      article
      <p>Problems with fatigue and sleep are highly prevalent in patients with chronic diseases and often rated among the most disabling symptoms, impairing their activities of daily living and the health-related quality ...

    • Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: A case-control study 

      -, -; Martinez-Majander, Nicolas; Kutal, Shakar; Ylikotila, Pauli; Yesilot, Nilufer; Tulkki, Lauri; Zedde, Marialuisa; Sarkanen, Tomi; Junttola, Ulla; Nordanstig, Annika; Fromm, Annette; Ryliskiene, Kristina; Licenik, Radim; Ferdinand, Phillip; Jatuzis, Dalius; Kõrv, Liisa; Kõrv, Janika; Pezzini, Alessandro; Tuohinen, Suvi; Sinisalo, Juha; Lehto, Mika; Gerdts, Eva; Ryödi, Essi; Autere, Jaana; Hedman, Marja; Fonseca, Ana Catarina; Waje-Andreassen, Ulrike; Von Sarnowski, Bettina; Redfors, Petra; Sairanen, Tiina; Tatlisumak, Turgut; Roine, Risto O.; Huhtakangas, Juha; Numminen, Heikki; Jäkälä, Pekka; Putaala, Jukka (2024)
      article
      Background: The underlying risk factors for young-onset cryptogenic ischaemic stroke (CIS) remain unclear. This multicentre study aimed to explore the association between heavy alcohol consumption and CIS with subgroup ...

    • Association of Hypertension With Early-Onset Cryptogenic Ischemic Stroke by the Presence of Patent Foramen Ovale: A Case-Control Study 

      -, -; Putaala, Jukka; von Sarnowski, Bettina; Schminke, Ulf; Busch, Raila; Martinez-Majander, Nicolas; Ylikotila, Pauli; Lautamäki, Riikka; Zedde, Marialuisa; Grimaldi, Teresa; Sarkanen, Tomi; Virtanen, Marko; Ryliskiene, Kristina; Zakarkaite, Diana; Tulkki, Lauri; Pirinen, Jani; Licenik, Radim; Ferdinand, Phillip; Oxley, Cheryl; Kõrv, Janika; Muda, Piibe; Pezzini, Alessandro; Lombardi, Carlo Mario; Tsivgoulis, Georgios; Suihko, Satu; Tolppanen, Heli; Fonseca, Ana Catarina; Martínez-Sánchez, Patricia; Amaya Pascasio, Laura; Yesilot, Nilufer; Elitok, Ali; Waje-Andreassen, Ulrike; Saeed, Sahrai; Redfors, Petra; Bech-Hanssen, Odd; Huhtakangas, Juha; Hedman, Marja; Jäkälä, Pekka; Sinisalo, Juha; Gerdts, Eva (05.11.2024)
      article

    • Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity: The TRIGR Nested Case–Control Study 

      -, -; Niinistö, Sari; Miettinen, Maija E.; Cuthbertson, David; Honkanen, Jarno; Hakola, Leena; Autio, Reija; Erlund, Iris; Arohonka, Petra; Vuorela, Arja; Härkönen, Taina; Hyöty, Heikki; Krischer, Jeffrey P.; Vaarala, Outi; Knip, Mikael; Virtanen, Suvi M. (25.05.2022)
      article
      <p>Aims: Altered immune functions as well as fatty acid intake and status have been associated with the development of type 1 diabetes. We aimed to study the relationship between fatty acids and immunological markers ...

    • Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk 

      -, -; Hård Af Segerstad, Elin M; Mramba, Lazarus K; Liu, Xiang; Uusitalo, Ulla; Yang, Jimin; Norris, Jill; Virtanen, Suvi M; Liu, Edwin; Kurppa, Kalle; Koletzko, Sibylle; Ziegler, Annette G; Toppari, Jorma; Rewers, Marian; Akolkar, Beena; Krischer, Jeffrey P; Aronsson, Carin Andrén; Agardh, Daniel; Ahonen, Suvi; Åkerlund, Mari; Hakola, Leena; Hyöty, Heikki; Koreasalo, Mirva; Oikarinen, Sami; Lönnrot, Maria; Mattila, Markus; Lindfors, Katri (12 / 2023)
      article
      <p>BACKGROUND: Higher gluten intake in childhood is associated with increased incidence of celiac disease autoimmunity (CDA) and celiac disease. It remains to be studied whether different dietary patterns independent ...

    • Azithromycin for bacterial watery diarrhea: A reanalysis of the AntiBiotics for Children with severe Diarrhea (ABCD) trial incorporating molecular diagnostics 

      -, -; Pavlinac, Patricia B; Platts-Mills, James; Liu, Jie; Atlas, Hannah E; Gratz, Jean; Operario, Darwin; Rogawski McQuade, Elizabeth; Ahmed, Dilruba; Ahmed, Tahmeed; Alam, Tahmina; Ashorn, Per; Badji, Henry; Bahl, Rajiv; Bar-Zeev, Naor; Chisti, Mohammod Jobayer; Cornick, Jen; Chauhan, Aishwarya; De Costa, Ayesha; Deb, Saikat; Dhingra, Usha; Dube, Queen; Duggan, Christopher P; Freyne, Bridget; Gumbi, Wilson; Hotwani, Aneeta; Kabir, Mamun; Islam, Ohedul; Kabir, Furqan; Kasumba, Irene; Kibwana, Upendo; Kotloff, Karen L; Khan, Shaila S; Maiden, Victor; Manji, Karim; Mehta, Ashka; Ndeketa, Latif; Praharaj, Ira; Qamar, Farah Naz; Sazawal, Sunil; Simon, Jonathon; Singa, Benson O; Somji, Sarah; Sow, Samba O; Tapia, Milagritos D; Tigoi, Caroline; Toure, Aliou; Walson, Judd L; Tahir Yousafzai, Mohammad; Houpt, Eric R (15.04.2023)
      article
      <p>BACKGROUND: Bacterial pathogens cause substantial diarrhea morbidity and mortality among children living in endemic settings, yet antimicrobial treatment is only recommended for dysentery or suspected cholera.&l ...

    • Benefits and barriers to accreditation of HPB center and fellowship programs in Europe: a strength-weakness-opportunity-and-threats (SWOT) analysis by an E-AHPBA-ESSO-UEMS ad hoc working committee 

      -, -; Soreide, Kjetil; Berrevoet, Frederik; Frigerio, Isabella; Gallagher, Tom; Laukkarinen, Johanna; Gilg, Stefan; Schnitzbauer, Andreas; Stättner, Stefan; Taboada, Cristina D.; Polak, Wojciech G.; Siriwardena, Ajith K.; Besselink, Marc G. (2024)
      article
      <p>Background: Training in HPB surgery lacks uniformity across regions covered by the E-AHPBA. Accreditation has been in place for centers and fellowship programs, but with low uptake. The decision whether to continue, ...

    • Biological and pathological mechanisms leading to the birth of a small vulnerable newborn 

      -, -; Hunter, Patricia J.; Awoyemi, Toluwalase; Ayede, Adejumoke I.; Chico, R. Matthew; David, Anna L.; Dewey, Kathryn G.; Duggan, Christopher P.; Gravett, Michael; Prendergast, Andrew J.; Ramakrishnan, Usha; Ashorn, Per; Klein, Nigel (20.05.2023)
      reviewarticle
      <p>The pathway to a thriving newborn begins before conception and continues in utero with a healthy placenta and the right balance of nutrients and growth factors that are timed and sequenced alongside hormonal ...