Trepo - Selaus tiedekunnan mukaan (- 2018)
Viitteet 41-60 / 160
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Contribution of ARLTS1 Cys148Arg (T442C) Variant with Prostate Cancer Risk and ARLTS1 Function in Prostate Cancer Cells
(2011)
articleARLTS1 is a recently characterized tumor suppressor gene at 13q14.3, a region frequently deleted in both sporadic and hereditary prostate cancer (PCa). ARLTS1 variants, especially Cys148Arg (T442C), increase susceptibility ... -
Contribution of the ARLTS1 Gene to Prostate Cancer Susceptibility
Acta Electronica Universitatis Tamperensis : 1325 (Tampere University Press, 2013)
ArtikkeliväitöskirjaEturauhassyöpä on miesten yleisin syöpä teollistuneissa maissa, myös Suomessa, ja se aiheuttaa toiseksi eniten miesten syöpäkuolemia. Vaikka eturauhassyöpä on hyvin yleinen sairaus, sen syntyyn vaikuttavat syyt ja riskitekijät ... -
Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses
(2012)
articleRNA interference (RNAi) is a major antiviral pathway that shapes evolution of RNA viruses. We show here that Nora virus, a natural Drosophila pathogen, is both a target and suppressor of RNAi. We detected viral small RNAs ... -
Copy Number Variants in the Kallikrein Gene Cluster
(2013)
articleThe kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases. We searched for copy number ... -
Copy Number Variation Analysis in Familial BRCA1/2-Negative Finnish Breast and Ovarian Cancer
(2013)
articleBackground Inherited factors predisposing individuals to breast and ovarian cancer are largely unidentified in a majority of families with hereditary breast and ovarian cancer (HBOC). We aimed to identify germline copy ... -
CRP gene variation affects early development of Alzheimer's disease-related plaques
(2011)
articleIntroduction We used the Tampere Autopsy Study (TASTY) series (n = 603, age 0-97 yrs), representing an unselected population outside institutions, to investigate the pathogenic involvement of inflammation in Alzheimer's ... -
Culture Conditions Affect Cardiac Differentiation Potential of Human Pluripotent Stem Cells
(2012)
articleHuman pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), are capable of differentiating into any cell type in the human body and thus can be used ... -
Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro
(2013)
articleBackground Oxidative modification of low-density lipoprotein (LDL) is a key event in the oxidation hypothesis of atherogenesis. We have previously shown that HDL does not protect LDL from oxidation in vitro, but is in ... -
Development of a Protein Conservation Analysis Pipeline and Application to Carbonic Anhydrase IV
(2013)
Pro gradu -tutkielma*Background and Aims * Conservation is a hallmark of inherent valuable function. Computational analysis of conservation of each amino acid in a protein provides targets for future computational or experimental research. ... -
Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer
(2011)
articleBackground The aim of the study was to develop a virtual microscopy enabled method for assessment of Ki-67 expression and to study the prognostic value of the automated analysis in a comprehensive series of patients ... -
Development of a serotype-specific detection method for the diabetogenic coxsackievirus B1
(2012)
Pro gradu -tutkielma -
Development of fully defined xeno-free culture system for the preparation and propagation of cell therapy-compliant human adipose stem cells.
(2013)
articleIntroduction Adipose tissue is an attractive and abundant source of multipotent stem cells. Human adipose stem cells (ASCs) have shown to have therapeutic relevancy in diverse clinical applications. Nevertheless, expansion ... -
Differentiation and Purification of Human Pluripotent Stem Cell-derived Neuronal and Glial Cells - graft designing for spinal cord injury repair
Acta Electronica Universitatis Tamperensis : 1051 (Tampere University Press, 2011)
VäitöskirjaIhmisen alkion kantasolut ovat pluripotentteja soluja jotka voidaan erilaistaa kaikiksi kolmeksi eri alkiosolukerroksen solutyypiksi. Alkion kantasolujen tehokas kyky jakaantua ja erilaistua hermosoluiksi ja hermotukisoluiksi ... -
Effects of Biochemical and Mechanical Signals on Osteogenic Differentiation of Adipose Stem Cells in Vitro
Acta Electronica Universitatis Tamperensis : 1294 (Tampere University Press, 2013)
ArtikkeliväitöskirjaAikuisen rasvakudoksesta saatavien kantasolujen erilaistaminen luusolujen suuntaan soluviljelyssä käyttäen biokemiallisia ja mekaanisia signaaleja Erilaiset luukudoksen vauriot vaikuttavat miljoonien ihmisten elämänlaatuun ... -
Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.
(2013)
articleIntroduction Currently, human adipose stem cells (hASCs) are differentiated towards osteogenic lineages using culture medium supplemented with L-ascorbic acid 2-phosphate (AsA2-P), dexamethasone (Dex) and beta-glycerophosphate ... -
Effects of exonuclease deficiency on the biochemical properties of the human mitochondrial replicase
(2013)
Pro gradu -tutkielma -
Efflux protein expression in human stem cell-derived retinal pigment epithelial cells
(2012)
articleRetinal pigment epithelial (RPE) cells in the back of the eye nourish photoreceptor cells and form a selective barrier that influences drug transport from the blood to the photoreceptor cells. At the molecular level, ... -
ETS1 Mediates MEK1/2-Dependent Overexpression of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Human Cancer Cells
(2011)
articleEGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of transcriptional targets mediating the oncogenic effects of the ... -
Evaluation of the cell-free mitochondrial DNA quantity in plasma as an aging biomarker candidate
(2012)
Pro gradu -tutkielmaBackground and aims: Individuals of the same species may have large variations in their ageing rates, especially notable at higher ages. Therefore, it is proposed that chronological age is not suitable for measuring ones ...
