Trepo - Selaus Tutkinto-ohjelman ja opintosuunnan mukaan
Viitteet 21-40 / 40
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Feature selection for classification of single amino acid variations
(2012)
Pro gradu -tutkielmaGenetic variations that lead to changes in amino acid sequences have the ability to cause structural and functional changes of proteins. All such variations do not show phenotypic effects, so it is important to have ... -
Finding secretion signals in protein sequences
(2009)
Pro gradu -tutkielmaBackground and aims: Signal peptides are central to biological processes in that they direct proteins to their proper destination after synthesis. If the signal sequence in a nascent was changed, the protein could end up ... -
Genome wide scan for prostate cancer susceptibility genes
(2008)
Pro gradu -tutkielmaBackground and aims: Prostate cancer is the leading cancer type in Finnish men. It was suggested that 5% to 10% of incident cases are attributed to rare, highly penetrated alleles in single gene forms of disease. The aim ... -
Genome-Wide Comparison of Copy Number Variations in Finnish Familial Prostate and Breast Cancers
(2012)
Pro gradu -tutkielmaAbstract Background and aims: Prostate and breast cancers are the most prevalent types of cancer in all Western countries including Finland. For both cancer types, there is a “missing heritability” - the genetic defects ... -
Identification of genes involved in T-cell differentiation
(2013)
Pro gradu -tutkielmaBackground: T-cells are involved in many immune functions. Each function is carried out by specific sub-set of T-cells. All T-cell sub-types originate from one stem cell and the fate of each cell is dictated by its pattern ... -
Identification of idh1 mutation-related gene signature of glioblastoma multiforme
(2014)
Pro gradu -tutkielmaBackground: Glioblastoma multiforme (GBM) is a type of commonly occurred malignant astrocytoma with an extremely poor prognosis. GBMs display a remarkable genetic variability, and it is essential to study the genomic ... -
Metagenomic tools and applications toward Type 1 Diabetes
Acta Electronica Universitatis Tamperensis : 1897 (Tampere University Press, 2018)
ArtikkeliväitöskirjaLaskennallinen mikrobipopulaatioiden havaitseminen tyypin 1 diabeteksen ulosteetäytteillä Ihmisen autoimmuunisairauksien puhkeamiseen vaikuttavat hyvin monenlaiset häiriöt solujen toiminnassa ja autoimmuunisairauksien ... -
Molecular effects of missense mutations - Bioinformatics analysis of genetic defects
Acta Electronica Universitatis Tamperensis : 968 (Tampere University Press, 2010)
VäitöskirjaTietoa ihmisen geneettisistä eroista saadaan nykyaikaisilla menetelmillä nopeasti, mutta niiden mahdollisista yhteyksistä sairauksiin ja geneettisten sairauksien molekyylitason mekanismeista ei ymmärretä vielä riittävästi. ... -
Mutational analysis of non-coding genome in prostate cancer using whole genome sequencing
(2014)
Pro gradu -tutkielmaProstate Cancer is a lethal disease characterized as progressive and possessing distinct molecular heterogeneity during its timespan. Vast number of abnormalities has been reported till now with number of somatic mutations ... -
Mutational effects on protein structures: Knowledge gained from databases, predictions and protein models
Acta Electronica Universitatis Tamperensis : 935 (Tampere University Press, 2010)
VäitöskirjaValkuaisaineet eli proteiinit ovat välttämättömiä elämää ylläpitäviä molekyylejä. Kaikkien proteiinien rakennusohjeet ovat perimässä ja ne rakentuvat 20 erilaisesta aminohaposta, joiden ominaisuudet ja järjestys määrittelevät ... -
Pentraxin -Carbonic anhydrase CA VI: A novel multidomain protein
(2012)
Pro gradu -tutkielmaTutkimuksen tausta ja tavoitteet: Hiilihappoanhydraasi- proteiinit (carbonic anhydrases, CAs) toimivat kudoksien ja nesteiden pH:n säätelyssä katalysoiden CO2 + H2O HCO3− + H+ reaktiota. Hiilihappoanhydraasit ovat ... -
Primary Immunodeficiency Information Knowledge Services
Acta Electronica Universitatis Tamperensis : 1209 (Tampere University Press, 2012)
VäitöskirjaTutkijat pystyvät tuottamaan uusilla menetelmillä suuria tietomääriä (esim. teksti- ja multimedialähteistä), mikä on haaste tutkijayhteisölle. Bioinformatiikan avulla voidaan madaltaa kynnystä tiedon hyödyntämiseen ... -
Protein-ligand interactions and their computational analysis using bioinformatics tools
(2015)
Pro gradu -tutkielma -
Proteomics: A tool for better understanding of celiac disease
(2011)
Pro gradu -tutkielmaBackground and aims: Celiac disease (CD) is a small intestine autoimmune disorder trigger by the ingestion of gluten containing cereals (wheat, barley and rye) in genetically predispose individuals (HLA-DQ2 or DQ8). The ... -
Pseudogenes and Gene Duplications Tell a Story of Evolutionary Fates of Animal Alpha Carbonic Anhydrases
Acta Electronica Universitatis Tamperensis : 1327 (Tampere University Press, 2013)
ArtikkeliväitöskirjaTässä väitöskirjassa on tutkittu hiilihappoanhydraaseja (CA), entsyymejä jotka muuttavat hiilidioksidia vetykarbonaatti-ioneiksi ja päin vastoin. Hiilihappoanhydraasit ovat tarpeellisia hengityksessä, happo-emästasapainon ... -
Sequence Conservation Metrics: Implementation and Comparative Analysis
(2009)
Pro gradu -tutkielmaBackground and Aims: Multiple Sequence Alignments (MSAs) help identify regions of similarity and dissimilarity between its constituent sequences, which is essential in understanding structural, functional and evolutionary ... -
Structural Analysis of Pathogenic Variations and Their Prevalence Across Protein-Protein Interface Regions of Human BTK Protein
(2013)
Pro gradu -tutkielmaBruton tyrosine kinase (BTK) belong to the Tec family of non receptor tyrosine kinases that is a predominant cytoplasmic protein found in cells of humans that is responsible for B-lymphocyte development, differentiation, ... -
The effect of pathogenic and neutral variants to the formation of nucleosome
(2013)
Pro gradu -tutkielmaBackground and Aims: Chromatin contains enormous genetic information, with further folding and compaction processes owing to the special structure of nucleosomes, which ensure the genetic continuity of organisms. The ... -
The evolution and function of the minimal mitochondrial DNA replisome
(2014)
Pro gradu -tutkielma -
Transcriptional regulation of bidirectional promoters: role of NF-Y
(2010)
Pro gradu -tutkielmaABSTRACT BACKGROUND: About 11% of human genes occur in divergent pairs such that both genes are located on opposite strands of DNA, and their immediate promoters are overlapping. The overlapping proximal promoter of both ...
