Trepo - Selaus tiedekunnan mukaan (- 2018)
Viitteet 21-40 / 160
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Banaanikärpänen : geneettisesti verraton mallieläin tutkimukseen
(2011)
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Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis
(2013)
articleBackground The Bag (Bcl-2 associated athanogene) family of proteins consists of 6 members sharing a common, single-copied Bag domain through which they interact with the molecular chaperone Hsp70. Bag5 represents an ... -
Bifunctional Avidin with Covalently Modifiable Ligand Binding Site
(2011)
articleThe extensive use of avidin and streptavidin in life sciences originates from the extraordinary tight biotin-binding affinity of these tetrameric proteins. Numerous studies have been performed to modify the biotin-binding ... -
Bioaktiivisten tripeptidien (IPP ja VPP) vaikutus ihmisen verisuonitonusta sääteleviin entsyymeihin ACE1, eNOS ja COX-2 napanuoran laskimon endoteelisoluissa (HUVEC)
(2011)
Pro gradu -tutkielmaTausta ja tavoitteet: Kohonnut verenpaine on vakava terveysongelma, johon nykytiedon mukaan voidaan vaikuttaa bioaktiivisia tripeptidejä (IPP ja VPP) sisältävällä ruokavaliolla. Vaikutusmekanismi on toistaiseksi puutteellisesti ... -
Bioinformatic analysis of next-generation sequencing data
(2012)
Pro gradu -tutkielmaBackround and aims:In a recent linkage study involving 69 Finnish HPC (Hereditary prostate cancer) families, a novel prostate cancer susceptibility locus 2q37.3 was found (Cropp et al. 2011). In addition a signal from ... -
BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment
(2013)
articleBackground Bone morphogenetic protein 4 (BMP4) belongs to the transforming growth factor β (TGF-β) family of proteins. BMPs regulate cell proliferation, differentiation and motility, and have also been reported to be ... -
BMP7 as a modulator of breast cancer growth and migration
(2011)
Pro gradu -tutkielmaBackground and aims: Breast cancer is the most common cancer in women in Western countries and a global health concern affecting millions of people. Thus the search for causative agents and possible curatives continues to ... -
Brave New Avidins
(2011)
Pro gradu -tutkielmaBackground and aims: The extremely high affinity of (strep)avidin towards biotin (Kd≈10-15-10-16) and stability enables its use in a variety of applications; for example, in targeted drug therapy, affinity chromatography ... -
Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study
(2011)
articleIntroduction Some molecular subtypes of breast cancer have preferential sites of distant relapse. The protein expression pattern of the primary tumor may influence the first distant metastasis site. Methods We identified ... -
Cardiac Differentiation of Pluripotent Stem Cells
(2011)
articleThe ability of human pluripotent stem cells to differentiate towards the cardiac lineage has attracted significant interest, initially with a strong focus on regenerative medicine. The ultimate goal to repair the heart by ... -
Cardiomyocyte MEA Data Analysis (CardioMDA) – A Novel Field Potential Data Analysis Software for Pluripotent Stem Cell Derived Cardiomyocytes
(2013)
articleCardiac safety pharmacology requires in-vitro testing of all drug candidates before clinical trials in order to ensure they are screened for cardio-toxic effects which may result in severe arrhythmias. Micro-electrode ... -
Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations
(2012)
articleBackground Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorders. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant inherited ion channel disorder ... -
Characterization of aberrant pathways across human cancers
(2013)
articleBackground Cancer is a broad group of genetic diseases which account for millions of deaths worldwide each year. Cancers are classified by various clinical, pathological and molecular methods, but even within a ... -
Characterization of Non-Specific Cytotoxic Cell Receptor Protein 1: A New Member of the Lectin-Type Subfamily of F-Box Proteins
(2011)
articleOur previous microarray study showed that the non-specific cytotoxic cell receptor protein 1 (Nccrp1) transcript is significantly upregulated in the gastric mucosa of carbonic anhydrase IX (CA IX)-deficient (Car9−/−) mice. ... -
Characterization of Pathogenic mutations in Kinase domain
(2013)
Pro gradu -tutkielmaBackground and aims:Protein Kinases having significant effects on signal transduction as well as most of the cellular processes, frequently causes diseases. A large number of disease-causing mutations have been recognized ... -
Cloning of UBAP2 and its role in prostate cancer
(2013)
Pro gradu -tutkielmaBackground and aims: Prostate cancer is a common malignancy affecting millions of men worldwide. The molecular mechanisms involved in prostate cancer are poorly understood. Genomic copy-number alterations are common in ... -
CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques
(2011)
articleIntroduction APOE is the strongest risk gene for sporadic Alzheimer's disease (AD) so far. Recent genome wide association studies found links for sporadic AD with CLU and CR1 involved in Aβ clearance, and PICALM affecting ... -
Comparison of Temperature Coupling Algorithms in SMD simulations and Mutation Design in Talin I/LWEQ Domain
(2013)
Pro gradu -tutkielmaRecently, a significant number of studies regarding the activation mechanism of talin's vinculin binding site (VBS) have been published. Since the hydrophobic VBS is in natural talin buried inside the helix structure, a ... -
Concordance between Pathway Databases and Refinement of Pathways for Computational Analysis
(2012)
Pro gradu -tutkielmaTutkimuksen tausta ja tavoitteet: Biologiassa tutkimus suuntautuu kokoajan kohti systeemitason tutkimusta. Enää ei tutkita vain yhtä tai muutamaa geeniä, vaan keskitytään kokonaisuuteen, jossa ne esiintyvät. Signalointireitit ... -
Construction of Chimeric Dual-Chain Avidin by Tandem Fusion of the Related Avidins
(2011)
articleBackground Avidin is a chicken egg-white protein with high affinity to vitamin H, also known as D-biotin. Many applications in life science research are based on this strong interaction. Avidin is a homotetrameric protein, ...
