Translation of clinical problems in osteoarthritis into pathophysiological research goals
van der Kraan, Peter M; Berenbaum, Francis; Blanco, Francisco J; Cosimo, de Bari; Lafeber, Floris; Hauge, Ellen; Higginbottom, Adele; Ioan-Facsinay, Andreea; Loughlin, John; Meulenbelt, Ingrid; Moilanen, Eeva; Pitsillidou, Irene; Tsezou, Aspasia; van Meurs, Joyce; Vincent, Tonia; Wittoek, Ruth; Lories, Rik; EULAR Study group in OA (2016)
van der Kraan, Peter M
Berenbaum, Francis
Blanco, Francisco J
Cosimo, de Bari
Lafeber, Floris
Hauge, Ellen
Higginbottom, Adele
Ioan-Facsinay, Andreea
Loughlin, John
Meulenbelt, Ingrid
Moilanen, Eeva
Pitsillidou, Irene
Tsezou, Aspasia
van Meurs, Joyce
Vincent, Tonia
Wittoek, Ruth
Lories, Rik
EULAR Study group in OA
2016
Rheumatic & musculoskeletal diseases Open 2 1
e000224
Lääketieteen yksikkö - School of Medicine
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:uta-201608102152
https://urn.fi/URN:NBN:fi:uta-201608102152
Tiivistelmä
Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent has a strongly ageing population and an obesity epidemic; obesity and age both being major risk factors for OA. No adequate therapeutic options, besides joint replacement, are available, although they are greatly needed and should be acquired by adequate research investments. However, the perspective on OA from a researcher's point of view is not always aligned with the perspective of a patient with OA. Researchers base their views on OA mainly on abnormalities in structure and function while patients consider OA as a collection of symptoms. In this viewpoint paper, we discuss the possibility of translating the most important clinical problems into pathophysiological research goals to facilitate the translation from bench to bedside and vice versa. This viewpoint is the outcome of a dialogue within the ‘European League Against Rheumatism study group on OA’ and People with Arthritis/Rheumatism across Europe (PARE) representatives.
Kokoelmat
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